One study in pregnant rats did show increased risk of fetal death and delays in development after birth. Azithromycin does pass into the breast milk of lactating women. These side effects may include diarrhea, vomiting, and rash. All possible dosages and drug forms may not be included here.
Your dosage, drug form, and how often you take the drug will depend on:. Typical dosage is mg once per day for 3 days. Your doctor may also prescribe mg taken as a single dose on day 1, followed by mg once per day on days 2 through 5. Your doctor may prescribe mg taken in a single dose on day 1, followed by mg once per day on days 2 through 5.
Your doctor may prescribe mg in a single dose on day 1, followed by mg once per day on days 2 through 5. For treatment , typical dosage is mg once per day, taken with the drug ethambutol.
However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. Always speak with your doctor or pharmacist about dosages that are right for you. Azithromycin is typically used for short-term treatment. For azithromycin to work well, a certain amount needs to be in your body at all times. If you take too much: You could have dangerous levels of the drug in your body. This may cause liver damage or an irregular heart rhythm.
If your symptoms are severe, call or go to the nearest emergency room right away. What to do if you miss a dose: Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects. If you take too much azithromycin, you could have dangerous levels of the drug in your body.
This may cause liver damage and irregular heart rhythm. A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription. A class of drugs is a group of medications that work in a similar way.
These drugs are often used to treat similar conditions. Azithromycin belongs to a drug class called macrolide antibiotics. Antibiotics are drugs used to treat infections caused by bacteria. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.
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See more conditions. Drugs and Supplements Azithromycin Oral Route. Products and services. Thank you for Subscribing Our Housecall e-newsletter will keep you up-to-date on the latest health information. If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for other ways to remember your medicine.
Taking an extra dose of azithromycin by accident is unlikely to harm you or your child. It may, however, increase the chance of temporary side effects, such as feeling or being sick or diarrhoea. Talk to your pharmacist or doctor if you're worried, or if you or your child accidentally take more than 1 extra dose.
Like all medicines, azithromycin can cause side effects, although not everyone gets them. These common side effects of azithromycin happen in more than 1 in people.
Keep taking the medicine, but talk to your doctor or pharmacist if these side effects bother you or don't go away:. In rare cases it's possible to have a serious allergic reaction anaphylaxis to azithromycin. These aren't all the side effects of azithromycin. For a full list, see the leaflet inside your medicine packet. Azithromycin isn't normally recommended during pregnancy or while breastfeeding. But your doctor may prescribe it if the benefits of taking azithromycin are greater than the risks.
Tell your doctor if you're taking these medicines before you start azithromycin:. You should also let your doctor know if you're taking any medicines for an irregular heartbeat arrhythmia , such as amiodarone or sotalol. Azithromycin can sometimes affect your heartbeat, so it's best not to take it with other medicines that have the same side effect. For this reason, it's important that you tell your doctor if you're taking medicines that can affect your heartbeat as a side effect.
Check the leaflets that come with your medicines and talk to a pharmacist or your doctor if you have any worries. There are no known problems with taking herbal remedies or supplements alongside azithromycin. Tell your doctor or pharmacist if you're taking any other medicines, including herbal medicines, vitamins or supplements.
Azithromycin is from a group of medicines called macrolide antibiotics. Macrolide antibiotics work by killing the bacteria that cause the infection. There are other macrolide antibiotics that work in the same way as azithromycin. They include erythromycin and clarithromycin. It's usual to take azithromycin once a day. For erythromycin, it's usually 4 times a day, and twice a day for clarithromycin.
Erythromycin is more likely to cause diarrhoea than either azithromycin or clarithromycin. All macrolides can be used to treat chest and skin infections. Azithromycin and erythromycin can also be used to treat sexually transmitted infections. Clarithromycin can also be used to treat Helicobacter pylori, bacteria that can cause stomach ulcers. Azithromycin and other macrolide antibiotics kill similar types of bacteria to penicillin antibiotics, such as amoxicillin.
Some people are allergic to penicillin antibiotics - they can take macrolides like azithromycin instead. It's very important that you keep taking azithromycin until your course is finished. Mirtazapine: Major Avoid coadministration of azithromycin with mirtazapine due to the increased risk of QT prolongation.
Mirtazapine has been associated with dose-dependent prolongation of the QT interval. TdP has been reported postmarketing, primarily in overdose or in patients with other risk factors for QT prolongation.
Moxifloxacin: Major Avoid coadministration of azithromycin with moxifloxacin due to the increased risk of QT prolongation. Quinolones have been associated with a risk of QT prolongation.
Although extremely rare, TdP has been reported during postmarketing surveillance of moxifloxacin. These reports generally involved patients with concurrent medical conditions or concomitant medications that may have been contributory. Nelfinavir: Moderate Coadministration of nelfinavir and azithromycin results in increased azithromycin concentrations.
Dosage adjustments are not necessary, although patients should be monitored for azithromycin related adverse effects such as increased hepatic enzymes and hearing impairment.
Nilotinib: Major Avoid coadministration of azithromycin with nilotinib due to the increased risk of QT prolongation. Sudden death and QT prolongation have been reported in patients who received nilotinib therapy. Norethindrone Acetate; Ethinyl Estradiol; Ferrous fumarate: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. Norethindrone: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics.
Norethindrone; Ethinyl Estradiol: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. Norethindrone; Ethinyl Estradiol; Ferrous fumarate: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics.
Norgestimate; Ethinyl Estradiol: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics.
Norgestrel: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. Nortriptyline: Major Avoid coadministration of azithromycin with tricyclic antidepressants TCAs due to the increased risk of QT prolongation.
Octreotide: Major Avoid coadministration of azithromycin with octreotide due to the increased risk of QT prolongation. Arrhythmias, sinus bradycardia, and conduction disturbances have occurred during octreotide therapy.
Since bradycardia is a risk factor for development of TdP, the potential occurrence of bradycardia during octreotide administration could theoretically increase the risk of TdP in patients receiving drugs that prolong the QT interval.
Ofloxacin: Major Avoid coadministration of azithromycin with ofloxacin due to the increased risk of QT prolongation.
Quinolones have been associated with a risk of QT prolongation and TdP. Although extremely rare, TdP has been reported during postmarketing surveillance of ofloxacin. Olanzapine: Major Avoid coadministration of azithromycin with olanzapine due to the increased risk of QT prolongation.
Limited data, including some case reports, suggest that olanzapine may be associated with a significant prolongation of the QTc interval. Olanzapine; Fluoxetine: Major Avoid coadministration of azithromycin with fluoxetine due to the increased risk of QT prolongation. Major Avoid coadministration of azithromycin with olanzapine due to the increased risk of QT prolongation. Olanzapine; Samidorphan: Major Avoid coadministration of azithromycin with olanzapine due to the increased risk of QT prolongation.
Olodaterol: Major Avoid coadministration of azithromycin with long-acting beta-agonists due to the increased risk of QT prolongation. Ondansetron: Major Avoid coadministration of azithromycin with ondansetron due to the increased risk of QT prolongation. Ondansetron has been associated with a dose-related increase in the QT interval and postmarketing reports of TdP.
Oral Contraceptives: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics. Osilodrostat: Major Avoid coadministration of azithromycin with osilodrostat due to the increased risk of QT prolongation.
Osilodrostat is associated with dose-dependent QT prolongation. Osimertinib: Major Avoid coadministration of azithromycin with osimertinib if possible due to the risk of QT prolongation and torsade de pointes TdP. An interruption of osimertinib therapy with dose reduction or discontinuation may be necessary if QT prolongation occurs.
Concentration-dependent QTc prolongation occurred during clinical trials of osimertinib. Oxaliplatin: Major Avoid coadministration of azithromycin with oxaliplatin due to the increased risk of QT prolongation.
QT prolongation and ventricular arrhythmias including fatal TdP have been reported with oxaliplatin use in postmarketing experience. Ozanimod: Major Avoid coadministration of azithromycin with ozanimod due to the increased risk of QT prolongation. Ozanimod initiation may result in a transient decrease in heart rate and atrioventricular conduction delays. Ozanimod has not been studied in patients taking concurrent QT prolonging drugs; however, QT prolonging drugs have been associated with TdP in patients with bradycardia.
Paliperidone: Major Avoid coadministration of azithromycin with paliperidone due to the increased risk of QT prolongation. Paliperidone has been associated with QT prolongation; torsade de pointes and ventricular fibrillation have been reported in the setting of overdose.
Panobinostat: Major Avoid coadministration of azithromycin with panobinostat due to the increased risk of QT prolongation. QT prolongation has been reported with panobinostat. Pasireotide: Major Avoid coadministration of azithromycin with pasireotide due to the increased risk of QT prolongation. QT prolongation has also occurred with pasireotide at therapeutic and supra-therapeutic doses.
Pazopanib: Major Avoid coadministration of azithromycin with pazopanib due to the increased risk of QT prolongation. Pazopanib has been reported to prolong the QT interval. Pentamidine: Major Avoid coadministration of azithromycin with pentamidine due to the increased risk of QT prolongation. Systemic pentamidine has been associated with QT prolongation. Perphenazine: Major Avoid coadministration of azithromycin with perphenazine due to the increased risk of QT prolongation.
Perphenazine is associated with a possible risk for QT prolongation. Theoretically, perphenazine may increase the risk of QT prolongation if coadministered with other drugs that have a risk of QT prolongation. Perphenazine; Amitriptyline: Major Avoid coadministration of azithromycin with perphenazine due to the increased risk of QT prolongation. Major Avoid coadministration of azithromycin with tricyclic antidepressants TCAs due to the increased risk of QT prolongation. Phenytoin: Minor Until more data are available, the manufacturer of azithromycin recommends caution and careful monitoring of patients who receive azithromycin with phenytoin.
Azithromycin was not implicated in clinical trials with drug interactions with phenytoin. However, specific drug interaction studies have not been performed with the combination of azithromycin and phenytoin. Pimavanserin: Major Avoid coadministration of azithromycin with pimavanserin due to the increased risk of QT prolongation.
Pimavanserin prolongs the QT interval. Pimozide: Contraindicated Pimozide is associated with a well-established risk of QT prolongation and torsade de pointes TdP. Because of the potential for TdP, use of macrolide antibiotics with pimozide is contraindicated.
Pirbuterol: Major Avoid coadministration of azithromycin with short-acting beta-agonists due to the increased risk of QT prolongation. Pitolisant: Major Avoid coadministration of azithromycin with pitolisant due to the increased risk of QT prolongation. Pitolisant prolongs the QT interval. Ponesimod: Major Avoid coadministration of azithromycin with ponesimod due to the increased risk of QT prolongation. Ponesimod initiation may result in a transient decrease in heart rate and atrioventricular conduction delays.
Ponesimod has not been studied in patients taking concurrent QT prolonging drugs; however, QT prolonging drugs have been associated with TdP in patients with bradycardia Posaconazole: Major Avoid coadministration of azithromycin with posaconazole due to the increased risk of QT prolongation. Posaconazole has been associated with prolongation of the QT interval as well as rare cases of TdP.
Pravastatin: Moderate Azithromycin has the potential to increase pravastatin exposure when used concomitantly. Primaquine: Major Avoid coadministration of azithromycin with primaquine due to the increased risk of QT prolongation. Primaquine has the potential for QT interval prolongation. Probenecid; Colchicine: Moderate Caution is warranted with the concomitant use of colchicine and azithromycin as increased colchicine concentrations may occur.
Procainamide: Major Avoid coadministration of azithromycin with procainamide due to the increased risk of QT prolongation.
Procainamide is associated with a well-established risk of QT prolongation and TdP. Prochlorperazine: Major Avoid coadministration of azithromycin with prochlorperazine due to the increased risk of QT prolongation. Prochlorperazine is associated with a possible risk for QT prolongation. Theoretically, prochlorperazine may increase the risk of QT prolongation if coadministered with other drugs that have a risk of QT prolongation.
Promethazine: Major Avoid coadministration of azithromycin with promethazine due to the increased risk of QT prolongation. Promethazine; Dextromethorphan: Major Avoid coadministration of azithromycin with promethazine due to the increased risk of QT prolongation.
Promethazine; Phenylephrine: Major Avoid coadministration of azithromycin with promethazine due to the increased risk of QT prolongation.
Propafenone: Major Avoid coadministration of azithromycin with propafenone due to the increased risk of QT prolongation. Protriptyline: Major Avoid coadministration of azithromycin with tricyclic antidepressants TCAs due to the increased risk of QT prolongation. Quetiapine: Major Avoid coadministration of azithromycin with quetiapine due to the increased risk of QT prolongation.
Limited data, including some case reports, suggest that quetiapine may be associated with a significant prolongation of the QTc interval in rare instances. Quinidine: Major Avoid coadministration of azithromycin with quinidine due to the increased risk of QT prolongation.
Quinine: Major Avoid coadministration of azithromycin with quinine due to the increased risk of QT prolongation.
Quinine has been associated with QT prolongation and rare cases of TdP. Ranolazine: Major Avoid coadministration of azithromycin with ranolazine due to the increased risk of QT prolongation. Ranolazine is associated with dose- and plasma concentration-related increases in the QTc interval. Although there are no studies examining the effects of ranolazine in patients receiving other QT prolonging drugs, coadministration of such drugs may result in additive QT prolongation.
Relugolix: Major Avoid coadministration of azithromycin with relugolix due to the increased risk of QT prolongation. Relugolix; Estradiol; Norethindrone acetate: Major Avoid coadministration of azithromycin with relugolix due to the increased risk of QT prolongation. Ribociclib: Major Avoid coadministration of azithromycin with ribociclib due to the increased risk of QT prolongation.
Ribociclib has been shown to prolong the QT interval in a concentration-dependent manner. The ribociclib ECG changes occurred within the first four weeks of treatment and were reversible with dose interruption. Ribociclib; Letrozole: Major Avoid coadministration of azithromycin with ribociclib due to the increased risk of QT prolongation. Rilpivirine: Major Avoid coadministration of azithromycin with rilpivirine due to the increased risk of QT prolongation.
Risperidone: Major Avoid coadministration of azithromycin with risperidone due to the increased risk of QT prolongation. Romidepsin: Major Avoid coadministration of azithromycin with romidepsin due to the increased risk of QT prolongation.
Romidepsin has been reported to prolong the QT interval. Salmeterol: Major Avoid coadministration of azithromycin with long-acting beta-agonists due to the increased risk of QT prolongation. Saquinavir: Major Avoid coadministration of azithromycin with saquinavir boosted with ritonavir due to the increased risk of QT prolongation.
Saquinavir boosted with ritonavir increases the QT interval in a dose-dependent fashion, which may increase the risk for serious arrhythmias such as TdP. Segesterone Acetate; Ethinyl Estradiol: Moderate It would be prudent to recommend alternative or additional contraception when oral contraceptives OCs are used in conjunction with antibiotics.
Selpercatinib: Major Avoid coadministration of azithromycin and selpercatinib due to the risk of additive QT prolongation. Monitor ECG and electrolytes and avoid other non-essential QT prolonging drugs if use together is required. Concentration-dependent QT prolongation has been observed with selpercatinib therapy. Sertraline: Major Avoid coadministration of azithromycin with sertraline due to the increased risk of QT prolongation. Sertraline's FDA-approved labeling recommends avoiding concomitant use with drugs known to prolong the QTc interval; however, the risk of sertraline-induced QT prolongation is generally considered to be low in clinical practice.
Its effect on QTc interval is minimal typically less than 5 msec , and the drug has been used safely in patients with cardiac disease e. Sevoflurane: Major Avoid coadministration of azithromycin with halogenated anesthetics due to the increased risk of QT prolongation. Short-acting beta-agonists: Major Avoid coadministration of azithromycin with short-acting beta-agonists due to the increased risk of QT prolongation.
Siponimod: Major Avoid coadministration of azithromycin with siponimod due to the increased risk of QT prolongation. Siponimod therapy prolonged the QT interval at recommended doses in a clinical study. Sodium picosulfate; Magnesium oxide; Anhydrous citric acid: Major Prior or concomitant use of antibiotics with sodium picosulfate; magnesium oxide; anhydrous citric acid may reduce efficacy of the bowel preparation as conversion of sodium picosulfate to its active metabolite bis- p-hydroxy-phenyl -pyridylmethane BHPM is mediated by colonic bacteria.
If possible, avoid coadministration. Certain antibiotics i. Therefore, these antibiotics should be taken at least 2 hours before and not less than 6 hours after the administration of sodium picosulfate; magnesium oxide; anhydrous citric acid solution.
Solifenacin: Major Avoid coadministration of azithromycin with solifenacin due to the increased risk of QT prolongation. Solifenacin has been associated with dose-dependent prolongation of the QT interval. TdP has been reported with postmarketing use, although causality was not determined. Sorafenib: Major Avoid coadministration of azithromycin with sorafenib due to the increased risk of QT prolongation. An interruption or discontinuation of sorafenib therapy may be necessary if QT prolongation occurs.
Sorafenib is also associated with QTc prolongation. Sotalol: Major Avoid coadministration of azithromycin with sotalol due to the increased risk of QT prolongation. Sotalol administration is associated with QT prolongation and TdP. Proarrhythmic events should be anticipated after initiation of therapy and after each upward dosage adjustment. Sunitinib: Major Avoid coadministration of azithromycin with sunitinib due to the increased risk of QT prolongation.
Sunitinib can cause dose-dependent QT prolongation, which may increase the risk for ventricular arrhythmias, including TdP. Tacrolimus: Major Avoid coadministration of azithromycin with tacrolimus due to the increased risk of QT prolongation. Tacrolimus may prolong the QT interval and cause TdP. Talazoparib: Moderate Monitor for an increase in talazoparib-related adverse reactions if coadministration with azithromycin is necessary.
Tamoxifen: Major Avoid coadministration of azithromycin with tamoxifen due to the increased risk of QT prolongation. Tamoxifen has been reported to prolong the QT interval, usually in overdose or when used in high doses. Rare case reports of QT prolongation have also been described when tamoxifen is used at lower doses. Telavancin: Major Avoid coadministration of azithromycin with telavancin due to the increased risk of QT prolongation.
Telavancin has been associated with QT prolongation. Telithromycin: Major Avoid coadministration of azithromycin with telithromycin due to the increased risk of QT prolongation. Telithromycin is also associated with QT prolongation and TdP. Terbutaline: Major Avoid coadministration of azithromycin with short-acting beta-agonists due to the increased risk of QT prolongation. Tetrabenazine: Major Avoid coadministration of azithromycin with tetrabenazine due to the increased risk of QT prolongation.
Tetrabenazine causes a small increase in the corrected QT interval QTc. Thioridazine: Contraindicated Coadministration of thioridazine and azithromycin is contraindicated due to an increased risk of QT prolongation. Thioridazine is associated with a well-established risk of QT prolongation and TdP. Tiotropium; Olodaterol: Major Avoid coadministration of azithromycin with long-acting beta-agonists due to the increased risk of QT prolongation.
Tolterodine: Major Avoid coadministration of azithromycin with tolterodine due to the increased risk of QT prolongation. Tolterodine has been associated with dose-dependent prolongation of the QT interval, especially in poor CYP2D6 metabolizers. Toremifene: Major Avoid coadministration of azithromycin with toremifene if possible due to the risk of additive QT prolongation.
Toremifene has been shown to prolong the QTc interval in a dose- and concentration-related manner. Trazodone: Major Avoid coadministration of azithromycin with trazodone due to the increased risk of QT prolongation. In addition, there are postmarketing reports of TdP. Triclabendazole: Major Avoid coadministration of azithromycin with triclabendazole due to the increased risk of QT prolongation.
Transient prolongation of the mean QTc interval was noted on the ECG recordings in dogs administered triclabendazole. Tricyclic antidepressants: Major Avoid coadministration of azithromycin with tricyclic antidepressants TCAs due to the increased risk of QT prolongation.
Trifluoperazine: Major Avoid coadministration of azithromycin with trifluoperazine due to the increased risk of QT prolongation. Trifluoperazine is associated with a possible risk for QT prolongation.
Theoretically, trifluoperazine may increase the risk of QT prolongation if coadministered with other drugs that have a risk of QT prolongation. Trimipramine: Major Avoid coadministration of azithromycin with tricyclic antidepressants TCAs due to the increased risk of QT prolongation. Triptorelin: Major Avoid coadministration of azithromycin with triptorelin due to the increased risk of QT prolongation.
Umeclidinium; Vilanterol: Major Avoid coadministration of azithromycin with long-acting beta-agonists due to the increased risk of QT prolongation. Vandetanib: Major Avoid coadministration of azithromycin with vandetanib due to an increased risk of QT prolongation and torsade de pointes TdP.
An interruption of vandetanib therapy or dose reduction may be necessary for QT prolongation. Vandetanib can prolong the QT interval in a concentration-dependent manner; TdP and sudden death have been reported in patients receiving vandetanib. Vardenafil: Major Avoid coadministration of azithromycin with vardenafil due to the increased risk of QT prolongation. Both therapeutic and supratherapeutic doses of vardenafil produce an increase in QTc interval.
Vemurafenib: Major Avoid coadministration of azithromycin with vemurafenib due to the increased risk of QT prolongation. Vemurafenib has been associated with QT prolongation.
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