Two of the COX-2 inhibitors were removed from the market because studies showed they were linked to higher risk of heart attack and stroke. That left one—celecoxib, or Celebrex—on the market, but the heart concerns led the FDA to require its maker, Pfizer, to pay for additional studies to ensure that celecoxib did not put people at increased risk of heart trouble.
Now the results of the study show that contrary to what doctors and regulators expected, celecoxib does not lead to any higher rates of heart events than ibuprofen or naproxen. Steven Nissen, chair of cardiovascular medicine at the Cleveland Clinic.
In almost every measure, ibuprofen looks worse, naproxen is intermediate and celecoxib is the best. The study, which is published in the New England Journal of Medicine and which Nissen will present at the American Heart Association annual meeting in New Orleans, involved more than 24, people with heart problems who needed to take an NSAID to treat conditions like arthritis and rheumatoid arthritis.
They were randomly assigned to take one of the three drugs for nearly two years and followed for another three years for heart attacks, stroke or death. The people assigned to celecoxib did not show any higher rates of these events than those taking ibuprofen or naproxen. When Nissen and his team looked at kidney problems, they found lower risk among those taking celecoxib than among people taking ibuprofen.
Nitin Damle, president of the American College of Physicians. The previous concerns about COX-2 inhibitors and heart problems led many internists to prescribe NSAIDs like ibuprofen and naproxen as their first-choice therapies for people with osteoarthritis and rheumatoid arthritis, he says.
They would only turn to celecoxib if people had stomach issues. Now that may change. But the proportion who stopped their treatment in each group was about the same, meaning that the results were unlikely to have been drastically different if they had continued.
Contact your doctor right away and stop taking ibuprofen. Some people have an allergic reaction to ibuprofen, but this is also rare. If you start to have trouble breathing or your face or throat starts to swell, contact your doctor right away and stop taking ibuprofen. If you have liver disease, talk to your doctor before taking ibuprofen. Stop taking ibuprofen and contact your doctor right away if you start to have any of the following symptoms:. Ibuprofen can be a safe and easy over-the-counter remedy OTC for minor aches and pains.
If you experience bothersome side effects or believe you may have taken too much, contact your doctor right away. You can reduce your risk of side effects by using the smallest possible dose for shortest possible time. You can overdose on ibuprofen. Taking more than the recommended dosage of ibuprofen or drinking a lot of alcohol significantly raises your risk of serious problems. Find out how. Ibuprofen and acetaminophen are drugs for mild to moderate pain. Learn how they compare. How different can they be?
Learn more to judge for yourself. A new study looking into adverse effects from medication use found that anticoagulants and diabetes agents send a significant amount of adults ages 65…. We all experience pain. Fortunately, there are many ways to manage pain, whether that means treating the source of the pain or coping with the pain….
Health Conditions Discover Plan Connect. Medically reviewed by Alan Carter, Pharm. How ibuprofen works Common side effects Serious side effects Heart attack and stroke Kidney and blood pressure changes Internal bleeding Allergic reaction Liver failure Takeaway Overview.
Understanding how ibuprofen works. As a general rule, though, Dr. Otherwise, it can ruin your stomach. As with any drug, you should ask your doctor how much ibuprofen, if any, is safe for you, based on your specific health issues and concerns. Morgan lays out a few important, commonsense guidelines to keep in mind before heading to the medicine cabinet and diving into that bottle of ibuprofen.
Your muscles are sore from a workout, so you take an ibuprofen. Your cramps are bad this week, so you take an ibuprofen. But is it safe to take so much? An internist discusses the risks and how to take ibuprofen correctly, sparingly and responsibly. Learn more about vaccine availability.
0コメント